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Strong allergic reactions to Diflucan, although rare, have been reported. Strong allergic reactions to Diflucan, although rare, have been reported. Diflucan is usually taken by mouth as a one-time only dose with or without food or as directed by your doctor. Fluconazole is commonly used for prophylaxis in transplant patients. In people with weak immune systems caused by cancer treatment. It is taken at the same time each day. Before placing your order from the online pharmacy. Fluconazole is used for the treatment of serious fungal infections, especially of the central nervous system.