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Beta-blockers work by blocking beta receptors that are found in various parts of the body. Treatment should be started with a beta-blocker rather than a diuretic. You should not stop taking this medicine suddenly, particularly if you have ischemic heart disease. Inderal is usually used in combination with clonidine to lower blood pressure, there is a risk of a rebound increase in blood pressure if the clonidine is stopped. Treatment should be started with a beta-blocker rather than a diuretic.