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Nexium is a type of medicine known as an acid pump inhibitor which works by decreasing the acid produced by acid pumps. Esomeprazole capsules should be applied one hour before meals and at the same time every day. You have ever had an allergic reaction, you will not be able to use this medication. Esomeprazole capsules should be taken at least one hour before a meal. Your doctor will tell you how long it will take to feel the full benefit of Nexium. Taking Esomeprazole? The infection that causes ulcers occurring just beyond the exit from the stomach. Nexium is available in a powdered intravenous formulation to be reconstituted for injection.