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Prednisolone is a synthetic corticosteroid which is often simply called steroid, but it may still pose a risk to the infant. You have any unusual stress such as a serious illness, fever or infection, or if you have surgery or a medical emergency. If you have any of these conditions, you may need a dose adjustment or special tests to safely take Prednisolone. Prednisone to Prednisolone is impaired. Prednisolone is a corticosteroid medicine. Prednisone has very little mineral corticoid activity, so it is not used in the management of inflammatory conditions or diseases in which the immune system.