Before taking Prednisolone, you should tell your doctor about all of your medical conditions and about all other medicines you are using. Prednisone is inactive in the body that cause inflammation. Deltasone may not work as effectively in people with liver disease whose ability to convert prednisone to Prednisolone is impaired. Prednisone and Prednisolone are members of the glucocorticoid class of hormones.