It in moderation while taking Diflucan. Fluconazole is a triazole antifungal agent that may be an easier treatment than a messy cream. Ask your health care provider any questions you may have about how to use Fluconazole. Fluconazole can pass into breast milk and may harm a nursing baby. Fluconazole is commonly used for prophylaxis in transplant patients. Fluconazole can pass into breast milk and may harm a nursing baby. Fluconazole is commonly used for prophylaxis in transplant patients. Fluconazole is commonly used for prophylaxis in transplant patients. Fluconazole works best if it is taken at the same time each day.