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Celecoxib does not prevent the progression of either type of arthritis. Celebrex works by blocking the action of a substance in the body by inhibiting the breakdown of Celecoxib in the body called cyclo-oxygenase. Celebrex is used to decrease growths found in the intestines of persons with a family history of this condition. Ask your doctor, nurse, or pharmacist any questions you may have about this medicine. This drug may rarely cause serious liver disease. This medication should not be used if you have certain medical conditions. Ask your doctor, nurse, or pharmacist any questions you may have about this medicine. Your treatment goals. Ask your doctor, nurse, or pharmacist any questions you may have about this medicine.