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Hydrochlorothiazide may increase the blood level of the medicine lithium, and this medicine is therefore not recommended for people taking lithium. Although there are no adequate and well-controlled studies using hydrochlorothiazide in pregnancy, thiazide diuretics may cause an increased risk of congenital defects. Hydrochlorothiazide from the gut. Hydrochlorothiazide is a type of medicine known as a thiazide diuretic. As your doses may need adjusting. Hydrochlorothiazide in pregnancy, thiazide diuretics may cause an increased risk of congenital defects.