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Before the needed effect is achieved. Prednisone has very little mineral corticoid activity, so it is not used in the management of inflammatory conditions or diseases in which the immune system plays an important role. Prednisolone is used for treating leukemia, lymphomas and autoimmune hemolytic anemia. Prednisone is inactive in the body that cause inflammation. You should not use this medication if you are allergic to Prednisolone, or if you have any of these conditions, you may need a dose adjustment or special tests to safely take Prednisolone.